SKIN HEALTH

UNRAVEL THE POTENTIAL OF YOUR ACTIVES
WITH RELEVANT IN-VITRO, 3D HUMAN MODELS

We bring a broad and solid expertise in human skin biology in different areas like Cell Biology, Molecular Biology and Vascular Immunology.

With our 16 years of overall primary cell human culture experience, coupled with multi-disciplinary research experience, we can provide support for most in-vitro R&D project phases.

We focus on obtaining meaningful information about your actives/compounds using multicellular co- culture 3D in-vitro models with primary cells isolated from Human Skin.

Beyond standard tests, we are very strong in designing the tests tailored specifically for your needs and questions.

SCIENCE IN FOCUS

We keep abreast of scientific progress in biology, biomedicine and biological mechanisms. Combined with our knowledge and experience, we can address specific questions with a new perspective, either by developing a completely novel model or by refining of existing methodologies.

YOUR PERSONALIZED PROPRIETARY MODEL 

The cosmetic industry regularly invests to develop novel models with potential for demonstrating innovative or improved solutions to real problems. We support the client’s wish to bring proprietary models first-to-market with our know-how and experience. We possess a strong foundation for implementing novel models with our experience in developing human primary cell cultures and precision tuning of the reagents that are key for their culture.

MAIN PRIMARY HUMAN SKIN CELL TYPES

TAK: Transiently Amplifying Keratinocytes; DF: Dermal Fibroblasts; Ad-MSC: Adipose derived Mesenchymal Stem Cells MC: Melanocytes; EC: Endothelial Cells; HFC: Hair Follicle Cells; KSC: Keratinocyte Stem Cells;  SMC: Smooth Muscle Cells; IC: Immune Cells, ex-vivo human full-thickness skin models. All of the above singly or in combination can serve as specific models to be used to establishing objectively mechanisms of action.

ETHICS

For all the cells or tissues utilized for in-vitro studies, we adhere to ethical guidelines and procure only anonymized tissues that have been discarded after surgical removal. All our cell or tissue providers have received an ethics approval and have obtained prior informed consent from donors.

TESTING

Tests can be customized as needed to strengthen or derive appropriate scientific evidence for your actives. It is also possible to perform experiments using human skin samples as ex vivo models.

SPECIALIZED AREAS

If you are interested in a new model development or functional assays related to immunotoxicity, vascular function (blood flow), reproductive toxicology or sensitization (allergy), please contact us personally. Just send us a message, we will contact you immediately: services@curiobiotech.com

FUNCTIONCELLTYPESAIM FOR THE MODELENDPOINTS
AgingTAK/DF/Ad-MSCUV/Chronologic aging/Oxidative stressAutophagy/Metabolism/Inflammatory markers/
Stem or progenitor cells maintenance/Aging markers
PigmentationTAK/MCMelanogenesis/Autophagy/
Melanosome degradation
ToxicityTAK/DF/MC/Ad-MSC/HFCGrowth or proliferation/Cell integrity/ Viability test
AntioxidationTAK/DF/
MC/Ad-MSC/HFC
UV/Oxidative stressInflammatory markers/ROS
FirmingDFExtracellular matrix synthesis and degradation
Wound healingTAK/DF/Ad-MSCScratch Inflammatory markers/Re-epithelialization
Sun protectionTAK/DFSolar/UV Genotoxicity markers
SoothingTAKInflammatory markers
MoisturizingTAK/DFHydration/Barrier markers
WrinklesAd-MSCAdipocyte differentiation
Hair growthHFCSpheroid formation/Colony formation/Stem cell markers
DetoxificationTAKDetoxifying enzymes/Metabolites
CorrosionTAKViability and cytokine assays

If you're in Switzerland we can meet in person.